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HWI Scientist First In World To Unravel Structure Of Key Breast Cancer Target Enzyme
The molecular details of Aromatase, the key enzyme required for the body to make estrogen, are no longer a mystery thanks to the structural biology work done by the Ghosh lab at the Hauptman-Woodward Medical Research Institute (HWI) in Buffalo, New York. Dr. Debashis Ghosh's solution of the three-dimensional structure of aromatase is the first time that scientists have been able to visualize the mechanism of synthesizing estrogen.
medicalnewstoday.com

Hormone Therapy Associated With Reduced Colorectal Cancer Risk
The combination of estrogen plus progestin, which women stopped taking in droves following the news that it may increase their risk of breast cancer, may decrease their risk of colorectal cancer, according to a report published in the January issue of Cancer Epidemiology, Biomarkers and Prevention, a journal of the American Association for Cancer Research.
medicalnewstoday.com

Scientists Identify Gene Linked To Spread Of Breast Cancer
A newly identified gene, called metadherin, might cause breast cancer tumors to spread and become resistant to chemotherapy, according to a study published Tuesday in the journal Cancer Cell, the Baltimore Sun reports.
medicalnewstoday.com

Understanding And Treating Triple-Negative Breast Cancer
Triple-negative breast cancer is a subtype of breast cancer that is clinically negative for expression of estrogen and progesterone receptors (ER/PR) and HER2 protein. It is characterized by its unique molecular profile, aggressive behavior, distinct patterns of metastasis, and lack of targeted therapies. Although not synonymous, the majority of triple-negative breast cancers carry the "basal-like" molecular profile on gene expression arrays.
medicalnewstoday.com

Clinical Trials Of Experimental Breast Cancer Vaccine Expected To Begin In Spring
Scientists from the University of Arkansas for Medical Sciences this spring expect to begin the first of two phases of clinical trials for a vaccine designed to prevent the recurrence of breast cancer, the AP/FoxNews.com reports.
medicalnewstoday.com

Interpretation Time For Screening Digital Mammograms: Is It Efficient?
Digital mammograms take longer to interpret than film-screen mammograms, according to a study performed at The University of Texas M.D. Anderson Cancer Center in Houston, Texas. The study included four radiologists who interpreted 268 digital screening mammograms and 189 film-screening mammograms.
medicalnewstoday.com

Daily Women's Health Policy Report Summarizes Latest Breast Cancer News
The following summarizes recent news coverage related to breast cancer. ~ Genetic testing: NPR's "All Things Considered" on Wednesday profiled members of a family as they decided whether to undergo genetic testing for mutations of the BRCA1 and BRCA2 genes, which are strongly linked to an increased risk of breast and ovarian cancer.
medicalnewstoday.com

In Breast Cancers With Poor Prognosis Gene Plays Dual Role
A new study reveals that the metadherin gene (MTDH) plays a role in both cancer metastasis and resistance to chemotherapy. The research, published by Cell Press in the January 6th issue of the journal Cancer Cell, identifies MTDH as a promising therapeutic target for high risk breast cancers.
medicalnewstoday.com

NYT Examines Challenges To Improving 'Personalized Medicine' For Breast Cancer, Other Diseases
The New York Times on Tuesday examined how improvements in genetic testing could affect "personalized medicine" for the treatment of breast cancer and other diseases in the future. Personalized medicine uses genetic screening and other tests to provide physicians with more information to tailor patients' treatments, the Times reports.
medicalnewstoday.com

Inflammatory Breast Cancer: A Complex Disease
This article reviews the following: "Molecular Determinants of the Inflammatory Breast Cancer Phenotype".
medicalnewstoday.com

Team Finds Breast Cancer Gene Linked To Disease Spread
A team of researchers at Princeton University and The Cancer Institute of New Jersey has identified a long-sought gene that is fatefully switched on in 30 to 40 percent of all breast cancer patients, spreading the disease, resisting traditional chemotherapies and eventually leading to death.
medicalnewstoday.com

Molecular Determinants Of The Inflammatory Breast Cancer Phenotype
Despite advances in multimodality treatment, inflammatory breast cancer (IBC) remains the most aggressive and lethal form of breast cancer. The use of primary human IBC cell lines and functional in vivo xenograft cancer models have revealed characteristics innate to IBC thought to confer a strong metastatic potential and aggressive phenotype.
medicalnewstoday.com

Gene Helps Breast Cancer Spread And Resist Chemo
Scientists in the US looking for genomic changes in breast tumor samples found that a gene called metadherin (MTDH) appears to play a dual role in both helping cancer spread (metastasis) and maintain resistance to chemotherapy. They said this research identifies MTDH as an important new target for the treatment of high risk breast cancers.
medicalnewstoday.com

Immutep Announces Positive Interim Results In Phase I/II Chemoimmunotherapy Trial In Breast Cancer
Immutep S.A. announced today interim results from its ongoing Phase I/II chemoimmunotherapy clinical trial in metastatic breast carcinoma. ImmuFact IMP321 was administered the day after weekly paclitaxel for six months. The interim results show a clinical response rate of 50 per cent compared to 25 per cent with paclitaxel alone. In addition, a robust immune response was observed in clinically-responding patients.
medicalnewstoday.com

Cyclophilin B Is A Possible New Target For Treating Breast Cancer
Dr. Charles Clevenger and colleagues at Northwestern University have uncovered that cyclophilin B may contribute to progression in breast cancer. Their report can be found in the January 2009 issue of The American Journal of Pathology. The protein cyclophilin B affects cell division, motility, and death, all of which are altered in cancerous cells. To explore the role of cyclophilin B-mediated gene regulation in breast cancer, Dr.
medicalnewstoday.com

UPCI Researcher Receives Grant To Study Breast Cancer Biomarkers
Susan G. Komen for the Cure has awarded Jean Johanna Latimer, Ph.D., assistant professor in the Molecular Genetics and Biochemistry Program at the University of Pittsburgh Cancer Institute (UPCI), a grant to develop biomarkers that will help identify which forms of a common, noninvasive cancer-ductal carcinoma in situ (DCIS)-will metastasize. The research, focusing in part on DCIS in African-American women, may eventually spare patients from unnecessary treatments.
medicalnewstoday.com

Medicare Rebate For Breast MRI, Australia
A Medicare rebate for an MRI breast scan will be available to women under 50 at high risk of breast cancer and with no symptoms from 1 February 2009. Being at high risk of breast cancer can cause significant anxiety. These scans can help reduce unnecessary concern, and help pick up breast cancer early.
medicalnewstoday.com

MRI Scans Funded For Younger Women At High Risk Of Breast Cancer, Australia
National Breast and Ovarian Cancer Centre welcomes the addition of two new items to the Medicare Benefits Schedule (MBS) for the use of Magnetic Resonance Imaging (MRI) in the surveillance and diagnosis of women under 50 years of age at high risk of developing breast cancer.
medicalnewstoday.com

New York Times Examines Reconstructive Surgery Options For Women With Breast Cancer
The New York Times on Tuesday examined reconstructive breast surgery options provided to cancer patients undergoing mastectomies. According to the Times, despite recent advances in reconstructive breast surgery procedures, many plastic surgeons fail to inform women about the extent of their options.
medicalnewstoday.com

Lymphedema Risk For Breast Cancer Survivors Increased By Obesity
Throughout the world, 10 million breast cancer survivors have a lifetime risk for developing lymphedema, a chronic condition that involves swelling of the limbs and impacts physical and psychosocial health. Second only to the recurrence of cancer, it is the most dreaded effect of breast cancer treatment.
medicalnewstoday.com

IU Simon Cancer Center's Tissue Bank Collecting Samples Jan. 10
Would you like to contribute to breast cancer research? You can help by donating a tissue sample to the Susan G. Komen for the Cure Tissue Bank at the IU Simon Cancer Center from 8:30 a.m. to 2:30 p.m. Saturday, Jan. 10, in the Hematology Clinic and Women's Center (second floor) in the new patient building of the Indiana University Melvin and Bren Simon Cancer Center, 1030 W. Michigan St.
medicalnewstoday.com

Fruit, Veggie Intake Doubled With Switch To Mediterranean Diet Plan
In a new study led by the University of Michigan Health System, women more than doubled their fruit and vegetable intakes and dramatically increased their consumption of "good" fats when they were counseled by registered dietitians and provided with a list of guidelines on the amount of certain foods they should eat each day. The six-month study of 69 women divided the participants into two groups.
medicalnewstoday.com

Baby Girl Free Of Breast Cancer Gene Due To Be Born Soon
The first British baby girl free of the faulty BRCA 1 gene, which significantly raises a woman's chances of developing breast cancer, is due to be born soon. The girl has been genetically selected to be free of the faulty gene. As an embryo, she was screened to make sure she did not have the faulty gene. The BRCA 1 gene passes the risk of breast cancer down generations. Experts say a woman who carries this gene runs a 50% to 85% risk of developing breast cancer.
medicalnewstoday.com

Extra-Virgin Olive Oil Has Anti-Cancer Components
Good quality extra-virgin olive oil contains health-relevant chemicals, 'phytochemicals', that can trigger cancer cell death. New research published in the open access journal BMC Cancer sheds more light on the suspected association between olive oil-rich Mediterranean diets and reductions in breast cancer risk.
medicalnewstoday.com

'Molecular Manual' For 100s Of Inherited Diseases Compiled By Researchers
An international research team has compiled the first catalogue of tissue-specific pathologies underlying hundreds of inherited diseases. These results provide information that may help treat conditions such as breast cancer, Parkinson's disease, heart disease and autism. The report from scientists at the Technical University of Denmark and Massachusetts General Hospital (MGH) will appear in the Proceedings of the National Academy of Sciences and has been published online.
medicalnewstoday.com

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